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Karen Leigh O'Brien
Karen Leigh O'Brien


Sunset came to Karen Leigh O’Brien, Tuesday, May 9, 2017, surrounded by her father, soulmate and closest friends. Sunrise was Saturday, July 28, 1962, in Florence, SC, the only child of Dr. Guy S. O’Brien Jr. and Billie Hughes O’Brien. Karen was a graduate of USC and an avid Gamecock Fan. Surviving is her father, soulmate-Gregory Caputo Jr, and loving and devoted animals, Tahoe, Bear, and Smoke Kitty all of the home. A gathering of friends to celebrate Karen’s amazing journey of life will be Sunday, May 14th at Cali Bakers Firehouse Restaurant, 910 Lake Arrowhead Road in Myrtle Beach, from 3:00PM until 5:00PM. In lieu of flowers Karen’s wish was to help local children who are battling cancer. Donations can be made payable to Karen’s Kids, c/o Meche’ Williams, PO Box 70921, Myrtle Beach, SC 29572.

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Faye Hickson

So sorry to hear about Karen.She such a sweet,loving and carrying young lady.I am so glad that I got to know Karen and Gregory. They were so much fun and such a lovely couple. Look forward to seeing you Gregory this summer.

Becky Pendergrass
Murrells Inlet

My thoughts and prayers are with you Dr.O'Brien.

Philomena Gaines
New York

Karen,such a beautiful,free and loving spirit.
May you rest in peace.

Kim and Manny Rojas
Oakdale, Pa

We were so sorry to hear about Karen's passing. We loved her infectious smile and being around such a happy soul. She fought a courageous battle and was always positive. Sending Doc and Gregory positive, happy thoughts at this difficult time.


Please accept my sincere condolences for the loss of your loved one, Karen. It breaks our hearts when death separates us from the ones we love so much. The Bible reminds us that God sees our pain and sorrow and has promised that soon, "death will be swallowed up forever."(Isaiah 25:8) He will heal our broken hearts by resurrecting our precious loved ones to life again."(John 6:40) Until then, I hope the beautiful memories of Karen and these promises from God comfort you in the days to come.

Becky Morton
GreenSea SC

Karen was the most genuine person I have ever known. Truely loved and left a deep imprint on my heart. Her smile could light up any room and will dearly be missed by all who knew her! Rest easy dear friend. Fly High with the Angels until we meet again ????

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